Background: The present study was conducted for evaluating the efficacy of combined supraclavicular- interscalene vs interscalene block under USG guided in patients undergoing Humerus shaft fracture surgery. Materials & Methods: A total of 50 patients with presence of humerus shaft fractures were enrolled and were randomly divided into two study groups as follows: Group 1: Interscalene + Supraclavicular block group, and Group 2: Interscalene block group. All the patients were scheduled for surgery. Block performance-related pain was evaluated using VAS (visual analogue scale) on a scale of 0 to 10 with 0 indicating no pain and 10 indicating severe excruciating pain. The extent of motor and sensory blockade was evaluated. The motor blockade was evaluated by rating the muscle contraction forces on a scale of 0 to 6. All the results were recorded in Microsoft excel sheet followed by statistical analysis using SPSS software.Results: Mean surgical time among the patients of group 1 and group 2 was 202.3 seconds and 191.7 seconds respectively. Non-significant results were obtained while comparing degree of sensory block in terms of VAS at C5, C5, C7 and C8 among the patients of the two study groups. While comparing the degree of motor block among the patients of the two study groups at median nerve and ulnar nerve, significant results were obtained. Conclusion: In order to achieve full postoperative pain coverage, brachial plexus blocks carried out under ultrasound guidance can be utilized in conjunction to safely limit the need for analgesia and anesthetic during surgery.