Background: To analyse the efficacy of low-dose ketamine for prevention of pain associated with propofol injection. Materials & Methods: A total of 40 subjects were enrolled. The age group included was between 20-55 years. The two treatment groups were included as Group A: pretreatment done with ketamine 100µg/kg with 20 subjects and group B: pretreatment with normal saline (1ml). The subjects with diabetes, allergic to ketamine or propofol, cardiovascular diseases etc. were excluded. Consent was taken. The results were analysed using SPSS software. Results: None of the patients in Group A reported experiencing moderate or severe pain at any of the three intervals, in contrast to patients in Group B (saline group). Conclusion: The administration of 100 micrograms per kilogram of intravenous ketamine, coupled with the use of a tourniquet as a pretreatment before propofol, proved effective in substantially the intensity of pain.