Diabetic patients' life expectancy has increased as a result of advances in therapies and research, as has the elderly population as a whole. Trace element-associated antioxidant enzymes are changed in diabetes. Many cohort studies have indicated that diabetes can disrupt trace element homeostasis.Early abnormalities in particular components may have a significant effect in altering insulin metabolism. The present study was conducted in the Department of Biochemistry. It was designed to estimate the alterations in the levels of serum Magnesium and Serum Zinc in type 2 diabetes mellitus patients with microangiopathic complications in comparison to those without these complications and their relation with oxidative stress, insulin resistance, and glycaemic control. The aim of this study is to correlate the serum Magnesium and Serum zinc andinsulin resistance levels in patients of type2 diabetes mellitus with and without micro vascular complications. The study was permitted by the Ethical Committee of Institution. A written informed consentwas attained from all the 600 participants, upon fulfilling the inclusion criteria. We concluded that mean blood magnesium and zinc levels were considerably lower in type 2 diabetics with problems compared to those without difficulties and the control group. These levels declined considerably during the course of diabetes. A momentous negative correlation was showed by Serum levels of Magnesium and Zinc with FBS,HbA1c,HOMA-IRandMDA. Current observations recommend that Screening panel in the risk detection and progression of diabetes should include the estimation of serum zinc, magnesium and copper estimation. Supplementation of Mg and Zn and recurrent one-to-one care of levels of both minerals in type 2 diabetic patients.