Background: Yeast is the most common cause of fungal infection. Historically, C. Albicanshas been known to us since 400 BC, when the renowned Greek physician Hippocrates identified a microbial infection and named it “thrush,” which is caused by this pathogen. The present study was carried out in the Department of Microbiology at the Mahatma Gandhi Memorial Medical College in Indore for a period of one year. August 2016 to August 2017 Sample size: All the clinical samples (15569) that are received in the Department of Microbiology laboratory. All the clinically suspected patients during the study period. Result:Candida non-Albicans was the major species, accounting for 98 of the total isolates. Candida Albicansconstituted 37. Other non-Albicans were C. Tropicalis (46), followed by C. Glabrata (22), C. Krusei (21), C. Parapsilosis (8), and C. lusitaniae. Conclusion: The foundation for early fungal aetiology detection is provided by this work. Earlier A correct diagnosis and knowledge of the drug and host characteristics involved are crucial for improving these patients' outcomes.