Introduction:Depression and anxiety are common mental disorders highly prevalent in patients with chronic medical illness. Patients receiving other medication along with antidepressants /anxiolytics are at high risk for the occurrence of greater side effects, drug interactions, toxicities.This study was planned to observe the antidepressant /anxiolytic prescription pattern in patients in medicine wards, especially with various medical co-morbidities. Methodology:Patients admitted in theMedicine wards of Burdwan Medical College & Hospital during the last 1 month with at least one antidepressant and/or anxiolytic prescription were included in the study. Data was collected from the indoor prescriptions of these patients. Demographic profile including co-morbid conditions were recorded. The overall and individual prevalence of antidepressant and/or anxiolytic drugs was determined and indication and rationality of use of the drug was assessed. Any potential drug that could have caused any interaction during the study period was identified and recorded. Results:Out of 516 patients, 138(26.7%) patients were prescribed anti-anxiety drugs, 51(9.88%) received antidepressants and 7(1.35%) received both. Benzodiazepines were the most prescribed anti-anxiety drugs. Alprazolam and Clonazepam were the top two benzodiazepines prescribed in patients. Among the antidepressants, tricyclic antidepressants were the most common. Most common of them was Amitriptyline. 7.2% patients were prescribed anti-anxiety drugs and13.7% received antidepressants without appropriate indications. Prescriptions with potential drug interactions were found in 22 patients. Conclusion:Both anxiolytics and antidepressants were more commonly prescribed in females. Anxiolyticprescription was maximum in cases of myocardial infarction while antidepressants were common on patients with chronic liver disease. 4.2% of the patients were prescribed drugs which had chances of potential drug interactions.