Background: A clinical comparison between 0.5% levobupivacaine and 0.5% levobupivacaine with dexamethasone 8 mg combination in brachial plexus block by the supraclavicular approach. Materials & Methods: A total of 20 subjects were enrolled. Ultrasound- guided supraclavicular brachial plexus (SCBP) block was given. Time for the first rescue analgesia, number of rescue analgesics required in 24 h and different block characteristics was assessed. Chi-square test and Student's t-test were used for statistical analysis. The results were analysed using SPSS software. P – value < 0.05 was considered as statistically significant. Results:A total of 20 subjects were enrolled. The request for first rescue analgesic was significantly earlier in Group S than Group D. In Group S, motor block- onset showed 10.42 min and in group D depicted 6.47 min. Conclusion: The addition of dexamethasone to levobupivacaine in SCBP blockade prolonged time for first rescue analgesia with prolonged duration of sensory and motor block.