Areca palm, Areca catechu L., is widely cultivated in several South and Southeast Asian countries. The seeds of this palm called areca nut, betel nut or supari is the common chewing substance all over the world since thousands of years as people believed that areca nut has lots of medicinal properties. Ancient systems of medicines like Ayurveda, Unani, Homeopathy, etc., considered areca nut as medicine since very long time. Recent scientific observations also support this and confirmed more than 25 different medicinal uses of this nut. Anticancer property is one among them. Lots of scientific data are now available to substantiate the anticancer property of area nut. Original published documents are retrieved by referring old scientific journals found in Research Institutions, searching in Google scholar, Pub Med, internet and other facilities by using appropriate keywords. The articles collected were thoroughly read and reviewed to avoid any ambiguity. More than 20 original research papers on anticancer property of areca nut were cited and discussed in this paper. It is interesting to note that even arecoline, the major active component of areca nut, was reported to be anticancerous both in vitro and in vivo studies. Even observations made on chewers of unadulterated traditional forms of betel quid containing areca nut revealed that such habits are good for human health.