Background:Laparoscopic cholecystectomy (LC), a procedure associated with significant hemodynamic alterations due to factors such as pneumoperitoneum, patient positioning, and hypercapnia resulting from CO2 absorption, had the paramount goal of achieving optimal postoperative pain control and swift recovery. Aim and Objective:To investigate the impact of perioperative infusion of Lidocaine versus dexmedetomidine on hemodynamic parameters in patients undergoing LC.Methodology:The study, a non-randomized controlled trial conducted in a hospital setting, took place from 2018-2019 in the department of anaesthesia at Subharti Medical College and Hospital, Dehradun, in India. In this study, patients of either gender between the ages of 18 and 60 were scheduled for laparoscopic cholecystectomy. To perform a laparoscopic cholecystectomy, 124 adult patients of either sex who had ASA grades I or II were admitted. They were randomly split into two groups of 62 patients each.Result:In Group D, the most prevalent side effect was observed to be bradycardia, occurring in a notable percentage of cases. Additionally, dry mouth was reported in 19.35% of instances, followed by hypotension in 12.90%, and hypertension in 3.22% of cases. Conversely, in Group L, the predominant side effect was noted to be bradycardia, documented in 22.58% of instances. Dry mouth was reported in 17.74%, hypotension in 9.67%, and notably, no instances of hypertension were recorded in this group.Conclusion:The study concluded that both lidocaine and dexmedetomidine infusions were effective and safe adjuvants for enhancing recovery after LC. However, the postoperative recovery profile was notably superior with dexmedetomidine infusion. This suggested that dexmedetomidine may be considered the preferred adjuvant, particularly in the context of outpatient laparoscopic surgery. The study encompassed dexmedetomidine, hemodynamic, perioperative, laparoscopic cholecystectomy, surgery, and Quality of Recovery (QoR).