Background: Anti-microbial are the most commonly prescribed class of drugs in the patients admitted in the orthopaedic department, prescribed for prophylaxis as well as for the treatment of infections. As per the World Health Organization (WHO) report around 30-40% of medications are not as per the guidelines. AIM: The study was conducted to evaluate the drug prescribing trends in the management of indoor patients of orthopaedic department and to promote rational use of drugs. Material & methods: This was a prospective, observational study conducted by the department of pharmacology in association with the department of orthopaedics, Sher-I-Kashmir Institute of Medical Sciences, Medical College and Hospital (SKIMS-MCH), Bemina, Srinagar, India. Results: A total of 620 patients were included in this study, average number of drugs per prescription was 2.08, percentage of Anti-Microbial Agents (AMA) 56.28%, percentage of drugs prescribed by generic name was 50.59%, percentage of drugs prescribed in injectable form was 61.37% while as 94.91% of the drugs were prescribed from National List of Essential Medicines (NLEM). Conclusion: The WHO prescribing indicators aim to promote the rational use of drugs as the use of AMA’s is common in the orthopaedic department therefore regular evaluation of drug prescribing pattern can help in providing the feedback thus promoting the rational use of drugs.