Objective: The aim of our study was to assess factors that influence the status of C - reactive protein upon neonatal admission subsequent to delivery. Methods: The CRP of one hundred full-term infants was determined at 12, 24, and 48 hours of age. Perinatal variables such as mode of delivery, gestational age, maternal autoimmune diseases and others were documented. The electronic medical record system was utilized to gather data on the neonatal demographics and condition at the time of birth, in addition to the maternal medical history and medication usage during pregnancy. Utilizing statistical software, the potential correlation between perinatal factors and CRP at the time of postnatal admission was analyzed. Results: The study examined a cohort of 100 neonates, of which 63 were male and 37 were female. The average gestational age (GA) of the infants was 35.74±3.30 weeks. In a multifactor logistic regression analysis, it was determined that maternal autoimmune diseases (P˂0.002), premature rupture of membranes (PROM) within 18 hours (P=0.023), and larger GA (P˂0.001) constituted independent risk factors for CRP≥8 mg/L. A cesarean section was an independent protective factor against CRP8 mg/L (P0.001).A total of 100 neonates were analyzed, including 63 males and 37 females with a mean gestational age (GA) of 35.74±3.30 weeks. Multifactor Logistic regression analysis: larger GA (P˂0.001), premature rupture of membranes (PROM)≥18 h (P=0.023) and maternal autoimmune diseases (P<0.002) were independent risk factors for CRP≥8 mg/L. Cesarean delivery (P<0.001) was independent protective factor for CRP≥8 mg/L. Conclusion: GA, PROM, maternal autoimmune diseases, cesarean delivery and maternal autoimmune diseases were all found to have an independent impact on neonatal CRP≥8 mg/L at admission. Additionally, GA and neonatal CRP≥8 mg/L on admission exhibited a nonlinear relationship.