Background: GPF (greater palatine foramen) is seen at the articulation of the maxilla and hard palate on its posterior part which continues upward and posteriorly as GPC (greater palatine canal) and has an opening in the pterygopalatine fossa. The maxillary nerve exits the foramen rotundum and enters the pterygopalatine fossa where the nerve can be blocked with high success and low complications. This nerve block is vital for various oral surgical procedures. Aim: The study was aimed to accurately locate the patency, shape, and position of a greater palatine foramen in Indian subjects that can help in the intraoral maxillary nerve block approach. Methods: In 60 dried skull bones from adult subjects of both genders, patency, and shape of greater palatine foramen were assessed along with the molar relationship. The data collected were assessed statistically. Results: The study results depicted that bilaterally on all the skulls, greater palatine foramen was seen opposite to third molars in 91% of the studied skulls. The shape was most commonly found to be oval in 54% of skulls, and the patency rate was found to be 96%. Conclusion: The study with its data comparison and analysis showed that patency, shape, and position of greater palatine foramen can change based on the racial perspective. The study also showed that it is easier and safer to attain maxillary nerve block through greater palatine foramen owing to the consistency of the patency, shape, and position of the greater palatine foramen in the Indian subjects.