Aim:Negative pressure wound therapy in management of abdominal wound dehiscence: a case control study. Material and methods: This research included a total of 100 patients. Among the total of 100 participants, 50 were selected as the experimental group, where intervention was performed using VAC Therapy. The remaining 50 participants were assigned to the control group, where just NS dressing was applied. The main intervention was the use of NPWT, which could be administered by several methods such as vacuum-assisted closure (VAC system) or simple closed-system suction drainage. Alternatively, the AB thera system may be used constantly or intermittently for a certain duration. The comparison was conducted using a basic Normal saline dressing. Results: The majority of patients in this research were between the age range of 45-65 years. The youngest patient was 9 months old, while the oldest patient was 78 years old. The average age affected is 45.77±5.45 years. In our research, the occurrence of abdominal wound dehiscence was more prevalent among men, with 70 cases (70%), compared to females, with 30 cases (30%). The male to female ratio was 2.33 to 1. The most prevalent form of abdominal wound dehiscence was partial thickness wound dehiscence, accounting for 65 cases (65%), whereas full thickness wound dehiscence accounted for 35 cases (35%). In the current investigation, 45 out of the 50 cases had positive abdominal wound culture and sensitivity (c/s) results before the administration of Vacuum-Assisted Closure (VAC). After the application of VAC, 14 patients had positive c/s reports. The p-value of 0.001 indicates a high level of statistical significance. Secondary intention resulted in a healing rate of 50%, while the control group had a healing rate of 82%. The mortality rates in the cases group were much lower at 0% compared to the control group, which had a mortality rate of 2%. Conclusion: Our findings indicate that negative pressure wound treatment is a much superior method for controlling abdominal wound dehiscence and should be used in all feasible instances of abdominal wound dehiscence.