Background: Three pairs of big glands and the smaller oral mucosa glands create saliva. The present study was conducted to assess pH level and uric acid in saliva before and after complete denture insertion. Materials & Methods: 40 completely edentulous patients of both genders were selected. Subjects' saliva samples were taken right before their dentures were inserted to estimate pH and uric acid levels. Results: Out of 40 patients, males were 18 and females were 22. The mean pH of saliva before denture insertion was 6.2 and after denture insertion was 5.6. The difference was significant (P< 0.05). The mean uric of saliva before denture insertion was 4.9 and after denture insertion was 3.8. The difference was significant (P< 0.05). Conclusion: In total denture wearers, there were statistically significant reductions in salivary pH and uric acid levels.