Aim:The aim of the present study was to compare the effectiveness of negative pressure wound therapy with conventional dressings in the healing of infected chronic wounds. Material & Methods: The Present study was single-center, open labelled randomised control trial conducted in the Department of General Surgery and the study duration was of 36 months. 200 patients with chronic ulcers were randomly divided in two groups of 100 each as Group A (Negative Pressure Wound Therapy) and Group B (Conventional Dressing). Results: Participants in the study had an average age of 54.66 ± 12.8 years for the Conventional group and 53.7 ± 14.6 years for the NPWT group. No difference was statistically significant. Males dominated the traditional (65%) and NPWT (55%) groups. No difference was statistically significant. The present study indicated that 65% of chronic ulcers were diabetic, 25% venous, and 10% pressure. 95% of NPWT patients at 2 weeks and 55% of conventional group cases at 1 week developed granulation tissue, compared to 20% and 65% of conventional group cases. A statistical test showed a significant difference (p<0.01). Granulation tissue formed in 96% of NPWT patients and 86% of conventional cases after 3 weeks. NPWT accelerated wound contraction. In the first week, the wound healed unevenly. Disparity was detectable statistically (p<0.05). NPWT patients reduced wound size faster than typical patients. Starting in week 2, the difference was statistically significant (p<0.05). Although 88% of NPWT patients achieved closure with secondary aim, 72% of conventional patients and 12% of NPWT patients required skin grafting (p<0.05). Conclusion: The modified negative pressure wound treatment seems to be more effective than the usual dressing in early granulation tissue appearance, rapid contraction, faster healing, shorter hospital stays, and reduced expenses.