The overall national 5yr survival has been reported to vary in range according to tumor size {T1/T2 commonly referred to as “low risk tumor” & T3/T4 commonly referred to as “High risk tumor”}. The outcome is greatly influenced by the stage of the disease especially pathological TNM stage.Patient’s clinical parameters were recorded which include age, sex, tumor location, tobacco and alcohol use and medical history. Through clinical examination in which the site of the lesion and the extent of the lesion were assessed. The clinical staging was assessed by AJCC TNM staging. Comparison of PN status with cortisol levels was done using Mann-Whitney test. In PN+ group mean cortisol level was 13.34 with SD +_5.67 & in PN_group mean cortisol level was 12.71 with SD +_4.87. There was significant difference in the cortisol levels in both the groups since p=0.9346.