Aim: The purpose of this research is to investigate the efficacy of topical mitomycin C as an adjuvant in the treatment of ocular surface squamous neoplasia. Material and methods: Patients who had been given a diagnosis of OSSN and were above the age of 35 were considered for participation in the trial. A comprehensive history was obtained, including information on demographic characteristics, symptoms, their durations, and exposure to risk factors. Both the clinical exam and the cytological image were used to arrive at the conclusion that the patient had OSSN. Results: The OSSN reveals symptoms such as a sense of a foreign body in 6 participants (12%), a foreign body sensation plus a mass in 16 subjects (32%), and merely a mass in 22 subjects (with a high of 44%). Although damage and redness were seen in four of the patients (eight percent), just redness was observed in two of the subjects (four percent). The length of time that a person had OSSN was taken into consideration in the research. A greater number of individuals, or 19 (38%) of them, had OSSN for more than 8 months, whereas a smaller number of subjects, or 2 (4%), had OSSN for less than 3 weeks. 9 people were seen throughout the time of 3 weeks to 6 weeks, which corresponds to an 18% presence rate. In comparison, 4 subjects were seen for the duration of 3 months to 6 months, which corresponds to an 8% presence rate. There are many agents that can cause OSSN, but only four risk factors were considered for this study. Smoking was found to be a risk factor in 19 of the subjects (38 percent), while exposure to sunlight was found in 13 of the subjects (26 percent), and petroleum products were found in 7 of the subjects (14 percent). In 11 of the subjects, exposure to both sunlight and smoking was the risk factor that caused OSSN. Conclusion: The ophthalmology department often sees cases of OSSN, which is a dangerous kind of neoplastic illness. OSSN is rather prevalent. Wide excision is the conventional technique of therapy; nevertheless, this approach often results in a high risk of recurrence.