Aims And Objectives: To find an association of serum lipid profile in Type 2 Diabetes Mellitus with diabetic retinopathy. Study Period: 6 months. Study Design: Hospital based Prospective observational study. Study Population: Patients with Type 2 Diabetes Mellitus attending as in patient and out patient in Regional Institute of Ophthalmology, Gauhati Medical College. Targeted Sample Size: 250. Inclusion Criteria: Patients with Type 2 Diabetes mellitus with Diabetic retinopathy. Age between 20 to 80 years and both male and females will be included. Exclusion Criteria: Patients who were on lipid lowering drug, Bilateral media opacity and Pregnant patients.Patients on Haemodialysis,CAD and Hepatic Diseases. Materials And Methodology: 250 patients with Type 2 Diabetes Mellitus were selected and was categorized into patients with diabetic retinopathy and patients with no diabetic retinopathy. Serum lipid profile of both the groups were measured and compared. Results: Out of 250 patients,193 patients had diabetes with dyslipidemia and 57 patients had diabetes with no dyslipidemia.Mean ± SD of LDL(mg/dL) in patients with diabetic retinopathy was 119.85±40.50 which was significantly higher as compared to patients without diabetic retinopathy indicating a significant association of LDL(mg/dL) with diabetic retinopathy. Conclusion: Serum lipid profile which are derranged are supposed to play a major role in the progression of diabetic retinopathy. Elevated serum LDL levels were found to be a significant risk factor for diabetic retinopathy.