Introduction: Inherited disorder affecting dentin is known as dentinogenesis imperfecta. The pathognomonic features such as fracture and attrition are observed. Main etiology targets mutation in dentin sialophosphoprotein (DSPP). In order to improve aesthetics and function, early diagnosis should be done followed by appropriate management to prevent further deterioration of affected teeth. This systematic review deals with such disorder in an elaborate manner. Materials and methods: A detailed literature search was done pertaining to OMFP patients and their association with dentinogenesis imperfecta. Inclusion criteria include various studies done on the above based topics. Results: Grand total of 600 cases were identified from 300 papers published in English language literature. Of these 300, 270 were filtered narrowing down to 30 fully downloaded studies pertaining to the topic. Conclusion: Perspective from a dental practitioner should be done in an exceptional way in patients with OMFP in order to achieve long-term success.