The disease process of OA is often a complex interplay of constitutional and multiple risk factors such as ageing, female gender, genetic factors, obesity, repetitive use of the joint, previous trauma, and prior inflammation. Of these, obesity is the most common predisposing factor among knee and hip joint OA. The subjects who met the eligibility criteria were randomized in 1:1:1 into 3 groups of 80 each, to receive standard dose of either Aceclofenac, Diclofenac, or Paracetamol as per the age and weight respectively for 6 weeks after obtaining their informed consent. After randomization, each subject received the allotted drug with instructions as per the scheduled dosage and all the subjects were also instructed to continue the physical activity and physical therapy. There was higher incidence of GI adverse effects of Gastritis (42.5%), pain abdomen (10%), and epigastric pain (5%) in Diclofenac than the Aceclofenac and Paracetamol treated groups. Although not statistically significant, fewer patients experienced side effects in Paracetamol and Aceclofenac treated groups compared to Diclofenac. Non- compliance to the medication was not noted among all the studied groups.