NSAIDs are the cornerstone effective anti-inflammatory and analgesics recommended to alleviate persistent osteoarthritic pain and inflammation. NSAIDs such as Ibuprofen, Diclofenac, Aceclofenac, Celecoxib are in wide use and frequently available in over the counter formulations. A detailed history, complete physical examination and routine investigations were done for all the subjects. The subjects who met the eligibility criteria were randomized in 1:1:1 into 3 groups of 80 each, to receive standard dose of either Aceclofenac, Diclofenac, or Paracetamol as per the age and weight respectively for 6 weeks after obtaining their informed consent. On 6th week, the percentage of subjects responded to study medication with regards to pain and movement was higher in Aceclofenac group (48.8%) than compared to subjects treated with Diclofenac (37.5%) and Pracetamol (12.5%). Both Aceclofenac (53%) and Diclofenac (53%) treated subjects equally showed extreme response to the treatment with score 4 by Likert scale on 10th week compared to Paracetamol group (20%).