Background: The recent surge in industrialization and urbanization, coupled with the widespread use of fossil fuel-driven vehicles, has resulted in escalated pollution levels, particularly in major cities. This environmental deterioration has given rise to various health issues, including both acute and chronic diseases such as Chronic Obstructive Pulmonary Disease (COPD), Cardiovascular Diseases, Cerebrovascular Diseases, among others, leading to substantial mortality and morbidity. Auto rickshaw drivers, operating in environments abundant with pollutants, are particularly susceptible to the adverse effects of these environmental stressors. Objectives: The current study aimed to assess the prevalence of COPD among auto rickshaw drivers. Methods: A community-based cross-sectional study was conducted in 2023 in the four major areas of Gwalior city, encompassing 500 auto rickshaw drivers selected from ten Three-Seater Rickshaw (TSR) stands through simple random sampling. Consecutive drivers were enrolled from each stand. Data collection involved a structured questionnaire, and spirometry was performed using a handheld portable spirometer with adjusted values according to S K Chhabra’s formula for Indian Males. Statistical analysis was conducted using SPSS, applying chi-square tests. Results: The mean age of the study subjects was 40.2±7.9 years, falling within the age group of 21 to 60 years. COPD prevalence was determined to be 15.2% based on spirometry according to GOLD criteria. Statistically significant associations were identified with the age of the study subjects and the cumulative driving hours. However, no significant association was found with smoking status. Conclusion: The study revealed a higher prevalence of COPD among the auto rickshaw drivers. Given their status in the unorganized sector, there is a pressing need for pertinent policies to enhance their health status and overall well-being.