Background: The prevalence of portal vein thrombosis can vary depending on age, underlying hepatic disease, velocity of portal venous blood and pro-versus anticoagulant status of the patient. The present study was conducted to correlate portal vein thrombosis with the color doppler, in patients of chronic liver disease. Materials & Methods: 100 patients diagnosed as a chronic liver disease of alcoholic and non-alcoholic aetiologies of both genders were enrolled. A detailed history, clinical examination, and laboratory profile of the patients were recorded. All patients were subjected to fasting glucose, liver function test and the coagulation profile (Prothrombin time, INR). Results: Of the 100 study subjects in the present study majority were from age group 36 to 55 years of age (55%). The mean age of participants was 43.69±12.40. The majority of participants (90) have Hb value below 11 gm%. Serum bilirubin level was above normal in 47 participants. The SGPT/SGOT values were above normal in each 37 participants. Blood coagulation markers (INR in 39 and PT in 38) were above normal in participants. The 33 and 30 participants have below-normal serum albumin and platelet count values, respectively. The subjects with portal vein thrombosis have portal vein diameter 2.06±0.44 mm which was significantly higher (p<0.05) than those not having portal vein thrombosis. In biochemical markers the Child Pugh score was significantly associated with platelets count, INR and total bilirubin (p<0.05). Conclusion: Portal vein thrombosis could worsen the rate of hepatic decompensation and survival of cirrhosis. The prognostic value of PVT in cirrhosis remains a grayzone. Early diagnosis, treatment and monitoring of the patients can prevent the occurrence of PVT in liver cirrhosis and also improve the liver function and survival.