Abstract—The roots of Coleus forskohlii were shade dried and powdered. The powder was extracted with different solvents such as petroleum ether, chloroform, acetone and methanol. The Balb/C mice weighing between 25-30g were induced with DLA cells and treated with the extracts of Coleus forskohlii roots to evaluate the activity of the liver marker enzymes. The liver marker enzymes such as alkaline phosphatase, acid phosphatase, aspartate transaminase, alanine transaminase, lactate dehydrogenase were found to have increased in the serum, indicating the liver damage and were reduced significantly in the methanol extract treated mice.