Aim: this study was conducted to compare theefficacy of analgesia and side effects of epidural tramadol and epidural fentanyl. Materials and methods: The study sample comprised forty adult patients, ASA grade 1and11, who were undergoing gynecological, orthopedic, and general surgery procedures involving the lower abdomen, limbs, and respectively. The patients were divided at random into two categories. Each of Group A (Tramadol) and Group B (Fentanyl) contained 20 patients. The research was prospective in nature. Results: Group 'A' was administered a single bolus dose of Inj. Tramadol diluted in 10 ml of normal saline at a rate of 1 mg/kg. A single bolus dose of 1 mcg/kg of Inj. Fentanyl diluted in 10 ml of normal saline was administered to Group 'B'. A random selection of patients who presented with post-operative pain with VAS 2 and 3 were administered epidural fentanyl or tramadol. The pain relief was evaluated utilizing a visual analog scale, and the occurrence of adverse effects such as vertigo, nausea, urinary retention, itching, and respiratory depression were documented. The severity, duration, and onset of analgesia, as well as adverse effects, were evaluated utilizing the paired 't' test and 'z' test. Conclusion: Regarding the management of post-operative analgesia, we discovered that epidural fentanyl produced analgesia more rapidly, but at the expense of significant instances of itching. However, epidural tramadol provided superior analgesia in terms of both duration and intensity; this group, however, experienced notable occurrences of nausea and vomiting.