Introduction- Polycystic ovary syndrome (PCOS) is a disease, which is associated with metabolic syndrome like insulin resistance, abdominal obesity and cardiovascular disease. Since insulin resistance leads to chronic inflammation and it is well known that insulin resistance is present in PCOS, so that this study is aimed to see the level of inflammatory marker in the form of CRP and C3 complement in PCOS patient in comparison to age matched healthy women. Aim & Objectives- To estimate & compare the level of CRP and C3 complement in blood of PCOS and matched healthy women. Material & Methods- This was hospital based cross-sectional prospective study carried out in the Department of Obstetrics & Gynecology along with collaboration Biochemistry department of Index Medical College and Research Center, Indore. Study period was from1st January 2018 to 31st December 2019.A total 260 women of age between 15-45 years were included in the study were divided into two groups cases and control. Out of 260, 130 were diagnosed for PCOS and included in case study group and rest 130 were healthy women without any history of PCOS. Approximately 5ml overnight fasting blood sample was collected in red vaccutainer for CRP and C3 assessment from each participant. Result- The mean±SD of BMI in cases and controls were 32.97±8.466 and 22.87±2.470 respectively. The mean±SD for serum C3 complement was 160.66±29.155 and 127.48±35.60 for cases and control respectively, and for CRP it was 2.41±0.94 and 2.25±0.83 for cases and controls respectively. The level of C3 found statistically significant difference between the cases and controls. Conclusion- In the present study, result showed that the level of C3 was significantly higher in PCOS cases than control, and CRP in the PCOS group was more than control group but found not significant. The implementation of the results of the present study will help to ease the life of individuals living with PCOS