Many studies on Indian colorectal cancer patients have shown different type genetic Alterations compared to west and other parts of world. Blood samples were collected from 30 colorectal cancer patients admitted at department of surgical gastroenterology. One sample from each collected during preoperative period another sample on post-operative day 7.All the blood samples were collected in EDTA coated blood collection tubes. Stage wise distribution of our patients showed that 56.6% of our patients are of stage 3 followed by stage II, stage I, and stage IV respectively. In our study 93.3% patients underwent curative surgery remaining 6.7% patients underwent non curative resection. Among two patients of non-curative one had unresectable metastatic disease underwent diversion stoma another had locally advanced disease with obstruction though underwent resection, margin was positive.