Background: The obesity epidemic is a major threat to health in most countries. The international focus on obesity has led to a steep increase in the number of studies dealing with possible interactions between obesity and other diseases as well as the relation betweenobesity and physiology and pathophysiology of the various organs and tissues of the body.The interaction between obesity and thyroid dysfunction has been the topic of clinical importance and hence many studies had tried to explore this potential link. Aim & objective: The objective of this study was to investigate the prevalence of obesity in subjects with thyroid dysfunction. Study design: Observational cross sectional study. Methodology: In total 270subjects who were newly diagnosedwith thyroid dysfunctionin special investigation biochemistry laboratory of GMC Aurangabadwere duly informed about this study before enrollingthem in this research study. These study subjects were categorized on the basis of their values of thyroid hormones(FT3, FT4 &TSH) into four groups of overt hypothyroidism,subclinical hypothyroidism, overt hyperthyroidism and subclinical hyperthyroidism.Secondly these 270 study participants were again categorized on basis of theirrespective body mass indices(BMI) into three groups as normal weight, overweight and obese subjects. The BMIof the participants were compared with their respective thyroid dysfunction and the resulted data was subjected for statistical analysis. Method of sample analysis: Serum free T3, free T4, TSH were estimated in the central clinical laboratory on cobas e411 biochemistry immunoassay analyser which used the principle of electrochemiluminiscence for estimating these hormones. Method of statistical analysis: The statistical data was systematically analyzed by using chi square test to compare the statistical significance of prevalence rates between two study groups. Result: The prevalence rates of obesity and overweight BMIin both the hypothyroid groups (overt & subclinical) was found to be significantly higher(p= 0.019) as compared to its prevalence in overt as well as subclinical hyperthyroidism. Secondlythe prevalence rates of obesity and overweight BMIwas significantly higher statistically(p= 0.024) in both the hypothyroid groups (overt & subclinical) as compared to the prevalence of normal weight BMI in subjects with overt as well as subclinical hypothyroidism. Conclusion:This study conclude that as obesity is significantly prevalent in hypothyroidism, all individuals with obesity must be screened for thyroid dysfunctions.