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Volume 12 Issue 1 (January- March) 2023

Original Articles

Effect of adding dexmedetomidine to levobupivacaine in bilateral transversus abdominis plane block for post-operative analgesia after caesarean delivery
Dr. Alka Dave, Dr. Sonik Shah, Dr. Priyanka Purohit, Dr. Grishma Harshil Chavda

Background and Aims: TAP block is a simple and effective regional anaesthesia technique with a very low complication rate. Dexmedetomidine, an alpha 2 adrenergic agonist, is known to prolong the action of local anaesthetics in peripheral nerve blocks. We aimed to study the effect of Dexmedetomidine as an adjuvant to Levobupivacaine in TAP block after CS. Material and Methods: A randomized double-blinded study was done on 50 patients scheduled for CS. Group A patients (n=25) received 20ml of 0.25% Levobupivacaine bilaterally and Group B patients (n=25) received 19.5 ml of 0.25% Levobupivacaine + 50μg of Dexmedetomidine (total 20ml bilaterally) for TAP block. Patients were monitored 24 hours for postoperative analgesia, vital parameters and drug-related adverse effects. Rescue analgesia was provided with 100mg of Tramadol. Time for the first requirement of rescue analgesia and the total analgesic requirement was noted. Result: The two groups were comparable in terms of age, weight, and ASA grade 1 and 2. The mean time for the first requirement of rescue analgesia was significantly longer in Group B {test group,10.43 ± 2.65 hours} as compared to Group A {control group, 8.12 ± 2.49 hours}; (p<0.05). The total dose of Tramadol requirement was lesser in Group B as compared to Group A. Patients of both groups were vitally stable and did not have any drug-related side effects (p>0.05). Conclusion: The addition of Dexmedetomidine to Levobupivacaine increases the duration of analgesia and decreases the requirement of the total amount of rescue analgesia.

 
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