Background: The present study was conducted for comparing the lipid profile among obese and non-obese subjects. Materials & methods: A total of 100 obese subjects and 100 healthy controls were enrolled. Complete demographic and clinical details of all the subjects was obtained. A Performa was made and complete anthropometric variables were recorded separately. All the subjects were recalled in the morning and fasting blood samples were obtained. All the samples were sent for evaluation of lipid profile. All the results were recorded in Microsoft excel sheet. All the results were analyzed by using SPSS software. Results: Mean total cholesterol levels among obese and non-obese subjects was 189.2 mg/dL and 159.8 mg/dL respectively. Mean triglycerides levels among obese and non-obese subjects was 159.7 mg/dL and 118.6 mg/dL respectively.Mean HDL-C levels among obese and non-obese subjects was 38.1 mg/dL and 41.9 mg/dL respectively.Mean LDL- C levels among obese and non-obese subjects were 137.3 mg/dL and 110.7 8 mg/dL respectively. While comparing the total cholesterol levels, triglyceride levels and low-density lipoproteins levels among obese and non-obese subjects, significant results were obtained. Conclusion: Obesity is accompanied by unfavorable blood lipids patterns.