Introduction: Leprosy is a slowly progressive, infectious granulomatous disease caused by acid fast rod shaped bacillus Mycobacterium Leprae. Early diagnosis and prompt treatment can lessen the disease effects and render the patient non-infectious. correlating the clinical and histopathological findings with the bacteriological index (BI) obtained by SSSE( slit-skin smear examination) may be helpful in diagnosing, isolating, and successfully monitoring the treatment particularly in developing countries. Aim: This study aimed to analyze the correlation of clinical and histopathological findings with the BI in different types of leprosy at our institution. Materials and Methods: Data from all untreated patients, among both genders, voluntarily reporting to out-patient department and clinically fulfilling the WHO (world health organization) leprosy case definition and undergoing SSSE and skin biopsy for histopathological confirmation was included in this study. Results: Maximum number of cases were recorded in the third decade of life (27%) .Childhood leprosy was observed in 8% of cases. There was marked male predominance (72%) PB was the most frequent clinical type (61%) correlating 100% with BI of 0 on SSSE. The most common clinical presentation was that of single or multiple well-demarcated hypopigmented plaques with hypoesthesia (61%) and the most common histopathological diagnoses was BT (49%) followed by LL (24%), The overall correlation of the histopathological diagnosis and clinical diagnosis was 80%, which was a statistically significant correlation (P<0.05). Conclusion: In presence of ambiguous clinical features, confirmation of leprosy can be problematic and therefore correlation of clinical features and histopathological diagnosis with BI seems more helpful in typing the leprosy and can guide physicians to provide better patient care and management. All suspected patients should therefore undergo a skin biopsy for histopathological examination in order to rule in leprosy