Background: Diabetic type 2 dyslipidemia is recognized as a risk factor for the onset of cardiovascular disease, constituting a significant contributor to morbidity and mortality in individuals with diabetes. While LDL-cholesterol is conventionally employed as a marker for cardiovascular disease risk, alternative indicators such as lipid ratios, atherogenic index of plasma (AIP), and atherogenic coefficient have been identified as more effective predictors of cardiovascular disease. The objective of the current study is to assess non-HDL cholesterol, AIP, and other cardiac indices as indicators of cardiovascular disease risk in diabetic patients. Methods: A cross-sectional investigation was conducted within the Department of Biochemistry, involving a total of 120 participants. Among them, 60 were individuals with diabetes, and the remaining 60 constituted a control group comprising healthy individuals of both genders. Various anthropometric parameters such as age, weight, height, and blood pressure, along with biochemical parameters including fasting blood sugar, lipid profiles, cardiac risk ratio, atherogenic index of plasma, atherogenic coefficient, and non-HDL cholesterol, were meticulously measured. Results: The investigation revealed significant increases in fasting blood glucose, HbA1c, total cholesterol, triglycerides, and LDL-cholesterol, accompanied by a noteworthy decrease in HDL-cholesterol among diabetic patients compared to the normal healthy control group. Furthermore, cardiac indices such as Cardiac Risk Ratio (CRR), Atherogenic Index of Plasma (AIP), Atherogenic Coefficient (AC), and non-HDL cholesterol were observed to be significantly elevated in diabetic patients when compared to their counterparts in the normal healthy population. Conclusion: The current study draws the conclusion that lipid ratios offer greater clinical convenience and can serve as valuable indicators for evaluating cardiovascular complications in diabetic patients, surpassing the utility of relying solely on lipid profiles.