Background: Knowledge of socio-demographic profile and obstetric features and medical co-morbidities may help in early identification and treatment of patients with post-partum psychosis. The aim of this paper is to study the, socio-demographic profile, parity and obstetric, menstrual profile and medical co-morbidities of patients suffering from post-partum psychosis. A cross-sectional study at in-patient department of psychiatry, A.B.V. Medical College Vidisha was conducted. Methods: The study was conducted on fifty-one patients of post-partum psychosis admitted in psychiatry ward. Detailed socio-demographic characteristics, medical co morbidity, obstetric and menstrual profile along with psychiatric assessment were recorded in proforma specially designed for the study. Results: Bulk of our post-partum psychotic subjects (56.86%) were in the age range of 26-35 years with 78.43% of women were residing at rural areas. Most of subjects (33.33%) of post partum psychosis were educated up to middle school. 72.54% patients were belonging to lower socio-economic status and remaining to middle and high socioeconomic status. Majority of subjects (74.50%) were housewife. Family jointness reveals 72.54% and 27.45% of subjects trailed from joint and nuclear family, respectively. the maximum number of subjects (64.70%) were primipara with only 13.72% of subjects had history of obstetric complication in form of prolonged labour and post-partum heamorrhage. 41.17% subjects had cesarean delivery. 37.25% patients of puerperal psychosis were having menstrual irregularity and 62.74% had regular menstruation. In this study anemia (54.90%) was found most common medical co-morbidity followed by post partum infection (35.29%). Conclusions: Screening for psychiatric signs and symptoms during the postpartum period is necessary for early diagnosis and timely and appropriate care of sensitive groups, such as young age, primipara, and history of anemia, postpartum infection, and irregular menstruation. Since the majority of the patients came from rural areas, it is essential to create mental health facilities there as well, enabling this population to receive comprehensive care in addition to the medical services that are currently available.