Background: Retinoblastoma (RB) is one of the common tumors of the childhood which has variable local and distant metastases. There are different factors which can predict the possibility of metastasis and guide the further management. Case Series: Out of the 78 bone marrow procedures performed during the year 2022, seven bone marrows aspirations (BMA) were performed in the cases of RB. Complete blood count (CBC), peripheral blood smear (PBS), BMA and cerebrospinal fluid (CSF) cytology done in the cases of RB were reviewed. Out of the seven BMA, two cases showed presence of metastasis. CSF cytology revealed no atypical cells in all the cases. Conclusion: BMA and CSF cytology are simple procedures and both can provide valuable information. When all the above mentioned tests and procedures are correlated, they can help in guiding the treatment.