Background:The present study was conducted for detecting silent myocardial ischemia in patients with type 2 diabetes mellitus by a treadmill test. Materials & methods:A total of 100 consecutive middle aged asymptomatic diabetics and 100 healthy controls were enrolled. All the diabetics and controls were subjected to treadmill test and 24-hour ambulatory electrocardiographic monitoring. Coronary angiography was done in those who were positive in treadmill test or 24-hour ambulatory electrocardiographic monitoring. A baseline 12-lead resting ECG was performed to assess for infarction. Only patients without ECG changes of myocardial infarction underwent the exercise stress test. Results:A total of 100 consecutive middle aged asymptomatic diabetics and 100 healthy controls were enrolled. Out of 100 diabetic subjects, ST segment depression indicating silent myocardial ischemia was seen in 39 percent of the diabetic subjects and in 7 percent of the controls on treadmill test. On comparing statistically, the results were found to be statistically significant. Conclusion:For detection of silent myocardial ischaemia in diabetic patients TMT has a significant role.