Background: Despite various technical and diagnostic advances in the modern surgical era of diagnosing and managing breast lesions, the traditional triple assessment method still holds a gold standard in diagnosing breast lesions including the pathological, radiological, and clinical assessment. Aim: The present study was aimed at evaluating the accuracy of clinical, radiographic, and FNAC assessment as a preoperative diagnostic tool in subjects with breast lumps. Methods: The present clinical study assessed 200 female subjects with a mean age of 38.68±12.28 years and an age range of 10-65 years that presented with the breast lump to the institute. For all the included females, detailed history and demographics were recorded followed by comprehensive clinical assessment, radiographical evaluation, and FNAC assessment as screening and diagnostic assessment in study subjects. Results: The results of the present study were assessed as individual components as well as overall rate clinically and radiographically. The results obtained were compared with the results of the final histopathological assessment. It was seen that in diagnosing the malignant breast lesions, the physical examination had specificity and sensitivity of 95.31% and 90.86% respectively, whereas, radiography revealed specificity and sensitivity of 99.14% and 95.77% respectively. The sensitivity and specificity of FNAC were 95.73% and 99.14% respectively. Conclusions: Considering its limitations, the present study concludes that the assessment of breast lesions using the clinical, radiographical, and FNAC assessment forms a reliable criterion for assessment, diagnosis, and management of breast lesions.