Aim and objectives: The aim of the study was to analyse serum ferritin levels in COPD patients and its correlation with severity and grading of COPD. Materials and method: The present cross sectional study was conducted among 100 COPD patients of both genders in the department of medicine, CSS Hospital, Subharti Medical College, Meerut from December 2020 to August 2022. Results: According to GOLD criteria; Gold stage I+II, III and IV was reported among 44%, 30% and 26% of the subjects respectively. Maximum subjects were from the age group of >60 years (57%) followed by 51-60 years (39%). Males were comparatively more as compared to females. COPD severity also increases along with the increase in smoking pack- years consumption. Serum ferritin was found to be raised among 24% of the COPD patients. Maximum raised ferritin level was found among subjects with GOLD IV (34.62%) followed by Gold III (26.67%). Hence raised serum ferritin was associated with severity of COPD. According to Pearson correlation analysis, significant positive correlation (r=0.29, p=0.038) was found between ferritin level and severity of COPD. Conclusion: Hyperferritinemia was associated with severity of COPD because of inflammatory mechanisms independent of iron stores.