Background: This study was conducted for the Evaluation of the Effect of Fixed and Removable Appliances on Salivary Parameters (Salivary Flow Rate pH and Buffering Capacity) in Children Aged 5–12 Years. Material and methods: A total of 50 participants, ranging in age from 5 to 12 years and representing both genders, were selected for the study. These participants required intervention with either fixed or detachable appliances, such as space maintainers or habit-breaking appliances. Results: The gender distribution of participants in group I and II revealed that 60% (30) of the participants were males, while 40% (20) were females. The gender distribution was shown to be comparable in both study cohorts. In the first month, group I experienced a drop of 0.02 ± 0.06 mL/min, followed by a rise in the second and third month. Group II had a consistent increase at all subsequent assessment periods. An unpaired "t" test demonstrates a statistically significant disparity between the study groups in terms of saliva flow rate and buffering capacity after 1 month, as well as buffering capacity after 2 months. Conclusion: Fixed and detachable space maintainers or appliances can serve as areas where plaque can easily accumulate in youngsters, so it is important to maintain proper oral hygiene and stress its importance. Neglecting to follow a rigorous oral hygiene routine can result in significant loss of enamel minerals and the buildup of plaque, which can lead to changes in the bacteria present in the mouth and have harmful consequences.