Original Articles
Elevated prothrombin time and activated partial thromboplastin time with raised hepatic enzymes as predictor of progression to eclampsia | |
Dr. Gaddam Thapasya Reddy, Dr. Rashid, Dr. Amit Kumar, Dr. Jyoti Ahlawat | |
Introduction: Pre-eclampsia is a complex multisystem disease, diagnosed by sudden-onset hypertension (>20 weeks of gestation) and at least one other associated complication, including proteinuria, maternal organ dysfunction or uteroplacental dysfunction and this may progress to eclampsia also has neurological features. A recent survey bought to light that in India the 76.34% and 17% patients of pre-eclampsia are in 21-30 years and adolescent age group, respectively, with 81% of patients being primigravida. Liver diseasesmust be considered in pregnancy as due to physiological changes many alterations in hepatic excretory and synthetic functions are noted and these may be pathological also attributable to preeclampsia. Aims and objectives: To study whether severity of preeclamapsia is a factor for prediction to eclampsia.Liver transaminases alone or in conjunction with prothrombin time/international normalised ratio (PT/INR) and activated partial thromboplastin time (aPTT) may be used predictor of progression of pre-eclampsia to eclampsia. Material and Methods: 100 primigravida females who presented to this hospital antenatally and were diagnosed with preeclampsia after following criteria of the study. Observations: 11 females progressed to eclampsia and out of these 8 had mild and only three had severe preecalmpsia. Two females with isolated elevation of liver transaminases and six with elevated liver transaminases and coagulation parameters progressed to eclampsia. Conclusion: Progression of preeclampsia to eclampsia is independent of severity of preeclampsia pointing to multifactorial causes. Elevation of Prothrombin time/INR and activated partial thromboplastin time (both or singularly) may be used as predictive indicator of progression to eclampsia in preeclamptic patients with elevated liver transaminases. |
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