Background: Peripheral Arterial Disease is a condition in which there is a buildup of plaque in the arteries that supply blood to the limbs, typically the legs.The present study was conducted to assess the efficacy of Duplex Ultrasonography (DUS) and Multidetector Computed Tomography Angiography (MDCTA) in the evaluation of peripheral arterial disease of the lower limb. Materials & Methods: 60 patients of peripheral arterial disease of both genders underwent Duplex ultrasonography and MDCT angiography. Results: Out of 60 patients, males were 36 and females were 24. Common clinical findings were gangrene in 10 patients, grade 2 claudication in 22, grade 3 claudication in 24 and grade 4 claudication in 4 patients. The difference was significant (P< 0.05).MDCTA was statistically significant in the detection of the length of stenotic segments in comparison to Duplex ultrasound. The difference was significant (P< 0.05). The diagnostic accuracy of DUS and MDCTA for Collateral flow was 94% and 96% respectively, for vessel wall calcification was 96% and 98% and for thrombosis was 95% and 97% respectively. The difference was significant (P< 0.05). Conclusion: In the assessment of peripheral artery disease, duplex ultrasonography can be utilized as a preliminary imaging modality, followed by MDCT angiography. For the diagnosis and pre-interventional work-up of PAD, particularly in the infra-popliteal segments, MDCT angiography is more sensitive and specific.