Recent studies have demonstrated that reactive oxygen species (ROS) may be a plausible approach for treating cancer. However, the potential drawback is while many treatments halt carcinoma growth, they also have detrimental effects on normal tissue. Hence, creating a selective therapy would be advantageous. Our study utilized peroxide generating particles, sodium percarbonate (SPO), calcium peroxide (CPO), and magnesium peroxide (MPO), as an ROS delivery system, for targeting and killing hepatomas (HepG2), while having little to no effect on the normal healthy hepatic cells (hepatocytes). The relation between hydrogen peroxide and cell death was investigated in detail. All three peroxide delivery systems were able to reduce cell viability of the HepG2, while sustaining viability of the hepatocytes. All three systems also significantly reduced cell growth and colony formation of the HepG2 cells, whereas no significant change in the hepatocytes regarding morphological and growth patterns were observed. It was found that CPO was most effective at halting proliferative hepatomas. This data suggest that exploiting the intracellular hydrogen peroxide stress of hepatomas, may be a novel approach for targeting liver carcinomas in a selective manner. Also that peroxide is a beneficial tool for causing apoptosis of hepatomas.