Objectives: To evaluate the effect of phenytoin plus clobazam among generalized tonic-clonic seizure (GTCS) patients attending neurology out-patient department at tertiary care center in Gwalior district. Methods: Present study wasprospective study conducted between period of February 2019 to January 2020 on 45 patients receiving phenytoin plus clobazam for the treatment of patients with Generalized tonic clonic seizures. Mean, standard deviation, one-way repeated measures of ANOVA wereapplied and Bonferroni Adjustment calculated. P value <0.05 was considered to be statistically significant. Results: Average age of participants was 28.84±12.76 years with male to female ratio as 1:2. The mean of seizure frequency in the first visit,second visit and third visit was 3.38±0.96, 1.53±0.63 and 0.73±0.65 per monthsrespectively. Significant reduction was seen within the group as compared to baseline to 3rd month and 6th monthsvisits (P <0.01). Conclusion: It can be concluded that phenytoin plus clobazam for the treatment of generalized tonic-clonic seizure (GTCS) patients is effective.