Background: The present study was carried out at our tertiary care center to bring the cost of the NPWT to a much lower range, using low-cost alternative materials and the resources available to us in a hospital setup along with a considerable focus on the end results and the ease with which the dressings are possible. Materials & methods: A hospital based observational study was conducted with 60 patients to evaluate the effectivity of innovative and cost saving method of negative pressure wound management with available resources. Wound dimensions as well as surface area were assessed before the dressing and charted regularly. Culture swab (Pus culture/tissue culture) were taken before wound irrigation with normal saline with each dressing. The wound was assessed on each dressing and measurements were taken along with photographs. The gradual improvement thus can be measured if wound is contracting and granulation tissue is improving. The presence of granulation tissue, slough, discharge, exposed bone or tendon, necrosed tissue, bleeding etc. used for assessment and were recorded in the proforma. For the purpose of this study, a completely healed wound was defined as a wound where either, the skin could be approximated and ready for secondary suturing or the wound where granulation tissue has covered the wound surface up to the peri-wound skin and can now be considered for skin grafting. Results: The meanage of the patients was 54.33 ±13.62years. The total days of negative pressure wound therapy (NPWT) in majority of the patients (36.6%) was ≥14 days followed by ≤7 days (31.7%) and 8-13 days (31.7%).46 (76.7%) patients underwent skin grafting while 14 (23.3%) patients underwent secondary suturing. There was significant difference in wound area during follow-up period as per ANOVA test (p<0.05). There was significant difference in wound area during follow-up period as per ANOVA test (p<0.05). The most common type of organism was Staphylococcus Aureus present in 12 (20%) patients on Day 0 followed by E.coli (13.3%), P. Aeruginosa (11.7%), MRSA (5%), Streptococcus Pyogenes (5%), Acinetobacter (3.3%), Aerumonas Species (1.7%), B.H. Streptococcus (1.7%) and Enterococcus species (1.7%). There was significant difference in type of organism during follow-up period as per Chi-Square test (p<0.05). Conclusion: Management of wounds is always a challenging issue. Therefore; there is a need of application of newer and advanced modalities for management of wounds. Wound shows better outcome with negative pressure wound therapy when used as one of the treatment modalities.