Introduction: A study with the aim to compare the quality of life in spouses of patients diagnosed with Alcohol Dependence Syndrome and Opioid Dependence Syndrome was conducted in spouses of 50 patients with alcohol and opioid dependence syndrome each diagnosed and seeking treatment in outpatients and inpatient units of Department of Psychiatry, Pt.B.D. Sharma, PGIMS, Rohtak. Material and methods: Socio-demographic and clinical variable were compared using statistical testsamongst the two groups and the participants.In this study Severity was assessed by ASI lite assessed QOL by WHO QOL –BREF and Family burden by (burden assessment Schedule). Data was analyzed using statistical tests( mean ,standard deviation, p value ) to compare QOL of spouses of Alcohol dependence syndrome (ADS) and Opioid dependence syndrome (ODS). Results: our study showed that substance dependence (alcohol and opioid in our study) was associated with substantial burden for the family members, more for subjective and objective burdens in rural location with low income, and more for spouses with alcohol dependence group followed by spouses with opioid dependence group. Similarly, spouses of patients with Alcohol dependence syndrome had lower QoL as compared to the spouses of patients with opioid use disorder. Conclusion: substantial Attention should be given to the mental health issues so as to relieve the distress in this vulnerable population. We suggest directions for future research in this area.