Objective: To compare the feasibility, difficulties and post operative complications between appendectomy involving simple ligation with transfixation and conventional appendectomy involving simple ligation with stump burial in patients with clinical diagnosis of acute appendicitis. Material and Methods: This comparative study was conducted in General Surgery Unit II, NIMS Hospital, Jaipur, Rajasthan from June, 2022 to September, 2023 including 2 months follow-up in all cases. Fourty cases who underwent appendectomy for uncomplicated acute appendicitis were divided into two groups. Group A included all patients undergone simple ligation with transfixation following appendectomy and Group B included all patients undergone stump closure with invagination following open appendectomy. Each group consisted of 20 cases. Results: The mean age was 35.8 years in group A and 36.5 years in group B. In this study wound infection was 10% in patients undergoing burial of stump following appendectomy and 5% in simple ligation (p> 0.05). Mean hospital stay was 3.65 days in those with stump burial following appendectomy while in simple ligation with transfixation, it was 3.6 days (p > 0.05). There was one case of paralytic ileus in Group B (5%) while in group A there was none (p > 0.05). In group B, 15% of patients suffered from fever while in simple ligation with transfixation, it was 10% (p value > 0.05). Extra time was spent on burial of stump following appendectomy with mean 3:45 minutes. Conclusion: Simple ligation with transfixation of the stump is easy and less time consuming. There is no significant difference in the frequency of wound infection and shorter hospital stay between simple ligation with transfixation and simple ligation withburial of stump after appendectomy.