Introduction: Sexual dysfunction is known to affect all domains of sexual function, including desire , arousal ,erection, ejaculation and orgasm; It is generally underestimated , often neglected and poorly managed .If sexual dysfunction were an intrinsic function of psychotic disorders it would be evident in people with first episode psychosis and before the start of treatment with antipsychotic medication. Based on this objective of our study is to compare and assess the differences in sexual dysfunction (SD) in people diagnosed as schizophrenia in first episode psychosis (FEP) and healthy controls. Research design and methods: A case control study with a sample size of 100 including 50 cases in FEP diagnosed as schizophrenia based on ICD 10 criteria and 50 healthy controls Healthy controls were screened using MINI interview. The severity of cases group assessed by PANSS score. Both groups were assessed with Arizona Sexual Experience Scale (ASEX) and Changes in Sexual Functioning Questionnaire (CSFQ) – male and female clinical version for SD. Results: The sexual experience in cases group is significantly reduced than control group based on scores in ASEX scale. Comparing the sexual activity, the cases had lower percentage 76% when compared to controls 94%. On CSFQ, domains such as pleasure, desire, arousal and orgasm were studied, the results showed significant SD in cases compared to controls in all domains with percentage of 84% vs 12% in cases vs controls. On comparing the domains of sexual function with domains of PANSS, the SD patients had significant correlations with negative and general psychopathology domains. Conclusion: Based on literature review, it was first study done in FEP diagnosed as schizophrenia to evaluate sexual dysfunction in Indian population. We need to screen every patient in psychiatric OPD in FEP for baseline sexual functioning. This helps the patient in follow up to report further sexual difficulties which helps to improve treatment adherence and quality of life.