Background: The present study was conducted for assessing spectrum of clinical profile in COPD patients. Materials & methods: A total of 150 consecutive patients more than 20 years of age and visiting with the clinical presentation indicative of COPD were enrolled. After enrollment, spirometry was done and 120 patients were diagnosed with COPD as per GOLD guidelines. According to this, and FEV1/FVC ratio of less than 0.70 was taken as COPD’s diagnostic criterion. Complete demographic and clinical details of all the patients was obtained. A Performa was made and Spirometric findings were recorded separately. A detailed history was taken about symptoms such as a cough, expectoration, breathlessness, fever, and chest pain. Clinical examination and relevant investigations were done including chest radiography. All the results were recorded in Microsoft excel sheet followed by statistical analysis using SPSS software. Results: Fever, Cough, Breathlessness and Pallor was seen in 50.83 percent, 93.33 percent, 98.33 percent and 38.33 percent of the patients respectively. Icterus, clubbing, cyanosis and pedal edema was seen in 2.5 percent, 15.83 percent, 2.5 percent and 25.83 percent of the patients respectively. ‘Diabetes mellitus, Hypertension, Thyroid dysfunction and Ischemic heart disease was seen in 27.5 percent, 30.83 percent, 23.33 percent and 15.83 percent of the patients respectively. Serum creatinine and blood urea levels were found to be 0.9 mg/dL and 41.3 mg/dL respectively. Conclusion: The current study's results shed a great deal of light on the patients' presentations to the outpatient department, the most typical COPD presentation, and the co-morbidities that are prevalent in COPD cases. An insight for the ongoing management of COPD cases is provided by this image.