Introduction: Breast lesions are heterogeneous diseases that consist of several distinct entities with remarkably different characteristic features. Most of the breast lesions are well understood and well diagnosed while some of the unusual lesions and malignancies are less appreciated. Majority of the breast lesions initially present with a lump in the breast which is very sensitive for female patients due to which they might not report timely to the doctor for an examination. Even after clinical examination, histopathological confirmation plays a crucial role in the evaluation of many malignant and premalignant lesions. Objective: To study the spectrum of lesions in mastectomies categorizing them into benign and malignant lesions with significance on histomorphology. Materials and methods: Study was conducted in the department of pathology from 2017 July to 2022 June. All the specimens received as lumpectomies and mastectomies were considered. Trucut biopsies were excluded from the study. Specimens were fixed, processed, stained, and examined under binocular microscope for histopathology. All of them were categorized asnon-neoplastic and neoplastic. Observation and results: Among a total of 129 specimens received, 31 cases belonged to the age group between 20-30 with benign and malignant being 30 and 1 respectively. 24 cases of benign and 3 cases of malignant belong to the age group of 31-40. Most of the cases in the age group >50 belonged to malignant category and among all the malignant cases, common age group encountered was between 40 and 50. Conclusion: Even after advancements in the diagnostic world, histopathology remains the gold standard for confirmation of breast malignancies and premalignant lesions.