Background and Aim: Failure of root canal therapy is highly common in day to day routine dental practice. Ultimate failure is dependent upon several factors. Various researchers have tried several precaution methods to minimize these dilemmas. Incomplete debridement and cleaning is one of the prime factors responsible for failure of endodontic therapies. The sole aim of this in-vitro study was to assess the efficiencies of 3 newer irrigants in removal of Triple Antibiotic Paste and debris from the root canal spaces. Materials & Methods: This in vitro study was conducted on twenty four maxillary central incisors. Original length measurements and other stages were done in standard manner by K file systems. All sample teeth were divided into three study groups of 8 each. In group one samples, Sod-H3 root canal irrigant was used while in group two samples, Pyrax RC Clean was used. In group three samples, Rident R-CMCP root canal irrigant was used precisely. Single expert observer was asked to evaluate the stereomicroscopic pictures of all samples for the presence or absence of canal debris. Results thus obtained was compiled and sent for necessary statistical analysis. P value less than 0.05 was considered significant (p< 0.05). Results: All relevant data were sent for statistical analysis. Sod-H3 appears to be very efficient and showed 1 score in seven out of eight samples. Statistical description for group 1: Sod-H3 showed highly significant p value (0.02). Statistical description for group 2: Pyrax RC Clean showed non-significant P value. Statistical description for group 3: Rident R-CMCP also showed non-significant P value. ANOVA Analysis, for Group 1, 2 & 3 also confirmed highly significant P value. Conclusion: Within the limitations of the study authors concluded that Sod-H3 was highly efficient irrigant when compared to other two studied irrigants. Rident R-CMCP showed minimum irrigating efficiency therefore Sod-H3 has been suggested in difficult and cumbersome clinical situations.