Chloroprocaine is a short acting local anesthetic that is reliable and has a favorable safety profile to support the growing need for day care surgery.It is now being tested as a substitute for lidocaine in human spinal anesthesia. After obtaining the approval from institutional review board and the ethical committee, 60 ASA Grade I and Grade II patients who met inclusion and exclusion criteria who were undergoing short duration urology, lower limb and perianal surgeries were selected. In the present study, systolic blood pressure and mean arterial blood pressure readings were noted to be comparable between the two groups. Although baseline diastolic blood pressure readings and at 4, 50, 60, 70, 90, 100 minutes were noted to be comparable between the two groups but subsequent diastolic blood pressure values at 2, 6, 8, 10, 20, 30, 40, 80, 110 minutes were higher in Chloroprocaine with fentanyl group than Chloroprocaine with sterile water group and it was statistically significant. But the difference was not clinically significant and none of patient required pharmacological treatment.