Background: A primary goal of medical education should be to create positive attitudes toward the mentally sick and psychiatry in order to ensure optimal care for the mentally ill. We aimed to find out efficacy of one-hour didactic lecture in improving attitude of medical students. Methodology: This study was conducted as an intervention study on 363 medical students who attended the scheduled lecture on schizophrenia conducted by the Department of psychiatry at our hospital. Pretest attitude of medical student regarding schizophrenia was observed. One hour didactic lecture was conducted and students were asked to fill post test form. Results: Initially, 363 students were enrolled in the study but only 314 students filled the post test form.Educational intervention was helpful in change in the attitude towards only one factor i.e. about 43.8% students will not feel ashamed if people knew someone in their family was diagnosed with schizophrenia whereas that was observed in 46.5% students (p<0.05). However, attitude remained almost same before and after intervention (p>0.05). Conclusions: A small one-hour lecture maybe efficient in short term knowledge but is not enough to induce a change in the attitudes of medical students. Such lectures have to be conducted at regular intervals for a proper change in attitude and must include practical aspects of dealing with such patients. Such destigmatization will improve the quality of care received by the mentally ill tremendously. This non-stigmatizing approach will also improve the medical morbidities and mortalities among the schizophrenic patients.